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1

Quantitative Bioanalytical Methods Validation and Implementation: Best Practices for Chromatographic and Ligand Binding Assays

C. T. Viswanathan, Surendra Bansal, Brian Booth, Anthony J. DeStefano, Mark J. Rose, Jeffrey Sailstad, Vinod P. Shah, Jerome P. Skelly, Patrick G. Swann, Russell Weiner

Journal:

Pharmaceutical Research

Year:

2007

Language:

english

File:

PDF, 252 KB

english, 2007

2

Detailed Analysis of Insulin Absorption Variability and the Tissue Response to Continuous Subcutaneous Insulin Infusion Catheter Implantation in Swine

Hauzenberger, Jasmin R., Hipszer, Brian R., Loeum, Channy, McCue, Peter A., DeStefano, Mark, Torjman, Marc C., Kaner, Mahmut T., Dinesen, Alek R., Chervoneva, Inna, Pieber, Thomas R., Joseph, Jeffrey

Journal:

Diabetes Technology & Therapeutics

Year:

2017

Language:

english

File:

PDF, 831 KB

english, 2017

3

A primer-free method that selects high-affinity single-stranded DNA aptamers using thermostable RNA ligase

Yi-Tak Lai, Jeffrey J. DeStefano

Journal:

Analytical Biochemistry

Year:

2011

Language:

english

File:

PDF, 641 KB

english, 2011

4

Magnesium Potentiates Imipramine Toxicity in the Isolated Rat Heart

Jeffrey A Kline, Amy A DeStefano, JD Schroeder, RM Raymond

Journal:

Annals of Emergency Medicine

Year:

1994

Language:

english

File:

PDF, 897 KB

english, 1994

5

Effects of postharvest storage and dormancy status on ABA content, metabolism, and expression of genes involved in ABA biosynthesis and metabolism in potato tuber tissues

Luis Destefano-Beltrán, Donna Knauber, Linda Huckle, Jeffrey C. Suttle

Journal:

Plant Molecular Biology

Year:

2006

Language:

english

File:

PDF, 310 KB

english, 2006

6

Workshop/conference report—Quantitative bioanalytical methods validation and implementation: Best practices for chromatographic and ligand binding assays

C. T. Viswanathan, Surendra Bansal, Brian Booth, Anthony J. DeStefano, Mark J. Rose, Jeffrey Sailstad, Vinod P. Shah, Jerome P. Skelly, Patrick G. Swann, Russell Weiner

Journal:

The AAPS Journal

Year:

2007

Language:

english

File:

PDF, 595 KB

english, 2007

7

In Vitro Strand Transfer from Broken RNAs Results in Mismatch but Not Frameshift Mutations

Jeffrey J. DeStefano, Aarti Raja, Jason V. Cristofaro

Journal:

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

8

Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates

Jeffrey J. DeStefano, Rodolfo G. Buiser, Lisa M. Mallaber, Philip J. Fay, Robert A. Bambara

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1992

Language:

english

File:

PDF, 1.61 MB

english, 1992

9

Characterization of an RNase H deficient mutant of human immunodeficiency virus-1 reverse transcriptase having an aspartate to asparagine change at position 498

Jeffrey J. DeStefano, Weimin Wu, Jasbir Seehra, John McCoy, David Laston, Earl Albone, Philip J. Fay, Robert A. Bambara

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1994

Language:

english

File:

PDF, 1015 KB

english, 1994

10

A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming

Deena T. Jacob, Jeffrey J. DeStefano

Journal:

Year:

2008

Language:

english

File:

PDF, 665 KB

english, 2008

11

Kinetic analysiss of the catalysis of strand transfer from internal regions of heteropolymeric RNA templates by human immunodeficiency virus reverse transcriptase

Jeffrey J. DeStefano

Journal:

Journal of Molecular Biology

Year:

1994

Language:

english

File:

PDF, 1.16 MB

english, 1994

12

In vitro Synthesis of Long DNA Products in Reactions with HIV-RT and Nucleocapsid Protein

Reshma M. Anthony, Jeffrey J. DeStefano

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 811 KB

english, 2007

13

Effect of reaction conditions and 3AB on the mutation rate of poliovirus RNA-dependent RNA polymerase in a α-complementation assay

Jeffrey J. DeStefano

Journal:

Year:

2010

Language:

english

File:

PDF, 654 KB

english, 2010

14

Determination of the mutation rate of poliovirus RNA-dependent RNA polymerase

Virgen Rodriguez Wells, Stephen J. Plotch, Jeffrey J. DeStefano

Journal:

Year:

2001

Language:

english

File:

PDF, 171 KB

english, 2001

15

Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination

Heather A Baird, Yong Gao, Román Galetto, Matthew Lalonde, Reshma M Anthony, Véronique Giacomoni, Measho Abreha, Jeffrey J Destefano, Matteo Negroni, Eric J Arts

Journal:

Year:

2006

Language:

english

File:

PDF, 960 KB

english, 2006

16

Risk factors for coronary heart disease mortality among persons with diabetes

Destefano, Frank, Ford, Earl S., Newman, Jeffrey, Stevenson, John M., Wetterhall, Scott F., Anda, Robert F., Vinicor, Frank

Journal:

Annals of Epidemiology

Year:

1993

Language:

english

File:

PDF, 900 KB

english, 1993

17

Long-term risk of menstrual disturbances after tubal sterilization

DeStefano, Frank, Perlman, Jeffrey A., Peterson, Herbert B., Diamond, Earl L.

Journal:

American Journal of Obstetrics and Gynecology

Year:

1985

Language:

english

File:

PDF, 672 KB

english, 1985

18

Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase

Destefano, Jeffrey J., Mallaber, Lisa M., Fay, Philip J., Bambara, Robert A.

Journal:

Nucleic Acids Research

Year:

1993

Language:

english

File:

PDF, 6.92 MB

english, 1993

19

Structure/Function Mapping of Amino Acids in the N- Terminal Zinc Finger of the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein: Residues Responsible for Nucleic Acid Helix Destabilizing Activity †

Narayanan, Nirupama, Gorelick, Robert J., DeStefano, Jeffrey J.

Journal:

Year:

2006

Language:

english

File:

PDF, 323 KB

english, 2006

20

Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures

DeStefano, Jeffrey J., Bambara, Robert A., Fay, Philip J.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.00 MB

english, 1993

21

Mutations in the Ribonuclease H Active Site of HIV−RT Reveal a Role for This Site in Stabilizing Enzyme−Primer−Template Binding

Cristofaro, Jason V., Rausch, Jason W., Le Grice, Stuart F. J., DeStefano, Jeffrey J.

Journal:

Year:

2002

Language:

english

File:

PDF, 155 KB

english, 2002

22

Tighter Binding of HIV Reverse Transcriptase to RNA−DNA versus DNA−DNA Results Mostly from Interactions in the Polymerase Domain and Requires Just a Small Stretch of RNA−DNA †

Bohlayer, William P., DeStefano, Jeffrey J.

Journal:

Year:

2006

Language:

english

File:

PDF, 600 KB

english, 2006

23

Photoluminescence and electronic structure of thallium(1+) dicyanoaurate(1-): evidence for relativistic effects in thallium-gold and gold-gold interactions

Assefa, Zerihun., DeStefano, Frank., Garepapaghi, Mohammad A., LaCasce, Joseph H., Ouellete, Steve., Corson, Michael R., Nagle, Jeffrey K., Patterson, Howard H.

Journal:

Inorganic Chemistry

Year:

1991

Language:

english

File:

PDF, 1.10 MB

english, 1991

24

Analysis of Mutations Made during Active Synthesis or Extension of Mismatched Substrates Further Define the Mechanism of HIV-RT Mutagenesis †

Liesch, Gwyneth R., DeStefano, Jeffrey J.

Journal:

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

25

Novel Aptamer Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase

DeStefano, Jeffrey J., Nair, Gauri R.

Journal:

Oligonucleotides

Year:

2008

Language:

english

File:

PDF, 534 KB

english, 2008

26

Correction for Achuthan et al., Human Immunodeficiency Virus Reverse Transcriptase Displays Dramatically Higher Fidelity Using Physiological Magnesium Conditions In Vitro

Achuthan, Vasudevan, Keith, Brian J., Connolly, Bernard A., DeStefano, Jeffrey J.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 91 KB

english, 2015

27

The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids

DeStefano, Jeffrey J.

Journal:

Nucleic Acids Research

Year:

1995

Language:

english

File:

PDF, 1.73 MB

english, 1995

28

Alternative divalent cations (Zn2+, Co2+, and Mn2+) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity

Achuthan, Vasudevan, DeStefano, Jeffrey J

Journal:

BMC Biochemistry

Year:

2015

File:

PDF, 1.26 MB

2015

29

Alternative divalent cations (Zn2+, Co2+, and Mn2+) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity

Achuthan, Vasudevan, DeStefano, Jeffrey J

Journal:

BMC Biochemistry

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

30

Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function

Chauhan, Jay, Chen, Shen-En, Fenstermacher, Katherine J., Naser-Tavakolian, Aurash, Reingewertz, Tali, Salmo, Rosene, Lee, Christian, Williams, Emori, Raje, Mithun, Sundberg, Eric, DeStefano, Jeffrey

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

31

Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity

Alves Ferreira-Bravo, Irani, Cozens, Christopher, Holliger, Philipp, DeStefano, Jeffrey J.

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

32

The twenty-nine amino acid C-terminal cytoplasmic domain of poliovirus 3AB is critical for nucleic acid chaperone activity

Gangaramani, Divya R., Eden, Elizabeth L., Shah, Manthan, DeStefano, Jeffrey J.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

33

Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer

Miller, Matthew T., Tuske, Steve, Das, Kalyan, DeStefano, Jeffrey J., Arnold, Eddy

Journal:

Protein Science

Year:

2016

Language:

english

File:

PDF, 9.52 MB

english, 2016

34

Conformational states of HIV-1 reverse transcriptase for nucleotide incorporation vs. pyrophosphorolysis – binding of foscarnet

Das, Kalyan, Balzarini, Jan, Miller, Matthew T, Maguire, Anita R., DeStefano, Jeffrey J., Arnold, Eddy

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.88 MB

english, 2016

35

Kinetic Analysis of the Effect of HIV Nucleocapsid Protein (NCp) on Internal Strand Transfer Reactions †

Raja, Aarti, DeStefano, Jeffrey J.

Journal:

Year:

1999

Language:

english

File:

PDF, 103 KB

english, 1999

36

A Complementary Single-Stranded Docking Site Is Required for Enhancement of Strand Exchange by Human Immunodeficiency Virus Nucleocapsid Protein on Substrates That Model Viral Recombination †

Heath, Megan J., DeStefano, Jeffrey J.

Journal:

Year:

2005

Language:

english

File:

PDF, 539 KB

english, 2005

37

Lack of Association Between Hepatitis B Birth Immunization and Neonatal Death

Eriksen, Eileen M., Perlman, Jeffrey A., Miller, Alvin, Marcy, S. Michael, Lee, Hang, Vadheim, Constance, Zangwill, Kenneth M., Chen, Robert T., DeStefano, Frank, Lewis, Edwin, Black, Steven, Shinefie

Journal:

Pediatric Infectious Disease Journal

Year:

2004

Language:

english

File:

PDF, 245 KB

english, 2004

38

Correction to Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis—Binding of Foscarnet

Das, Kalyan, Balzarini, Jan, Miller, Matthew T., Maguire, Anita R., DeStefano, Jeffrey J., Arnold, Eddy

Journal:

ACS Chemical Biology

Year:

2016

File:

PDF, 104 KB

2016

39

Physiological Mg 2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro

Achuthan, Vasudevan, Singh, Kamlendra, DeStefano, Jeffrey J.

Journal:

Year:

2017

Language:

english

File:

PDF, 7.55 MB

english, 2017

40

Using a Concept Inventory to Reveal Student Thinking Associated with Common Misconceptions about Antibiotic Resistance

Stevens, Ann M., Smith, Ann C., Marbach-Ad, Gili, Balcom, Sarah A., Buchner, John, Daniel, Sandra L., DeStefano, Jeffrey J., El-Sayed, Najib M., Frauwirth, Kenneth, Lee, Vincent T., McIver, Kevin S.,

Journal:

Journal of Microbiology and Biology Education

Year:

2017

Language:

english

File:

PDF, 260 KB

english, 2017

41

An Evolutionary/Biochemical Connection Between Promoter- and Primer-Dependent Polymerases Revealed by Selective Evolution of Ligands by Exponential Enrichment (SELEX)

Fenstermacher, Katherine J., Achuthan, Vasudevan, Schneider, Thomas D., DeStefano, Jeffrey J.

Journal:

Journal of Bacteriology

Year:

2018

Language:

english

File:

PDF, 4.60 MB

english, 2018

42

A highly sensitive aptamer-based HIV reverse transcriptase detection assay

DeStefano, Jeffrey J., Ferreira-Bravo, Irani Alves

Journal:

Journal of Virological Methods

Year:

2018

Language:

english

File:

PDF, 389 KB

english, 2018

43

Nonnucleoside reverse transcriptase inhibitors (NNRTI) inhibit reverse transcriptase through a mutually exclusive interaction with divalent cation-dNTP complexes

DeStefano, Jeffrey J.

Journal:

Year:

2019

File:

PDF, 893 KB

2019

44

Nonnucleoside reverse transcriptase inhibitors (NNRTI) inhibit reverse transcriptase through a mutually exclusive interaction with divalent cation-dNTP complexes

DeStefano, Jeffrey J.

Journal:

Year:

2019

Language:

english

File:

PDF, 893 KB

english, 2019

45

Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

Das, Kalyan, Martinez, Sergio E., DeStefano, Jeffrey J., Arnold, Eddy

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.39 MB

2019

46

Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

Das, Kalyan, Martinez, Sergio E., DeStefano, Jeffrey J., Arnold, Eddy

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 1.39 MB

english, 2019

47

Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers that Bind HIV-1 Integrase with Picomolar Affinity

Rose, Kevin M., Alves Ferreira-Bravo, Irani, Li, Min, Craigie, Robert, Ditzler, Mark A, Holliger, Philipp, DeStefano, Jeffrey J.

Journal:

ACS Chemical Biology

Year:

2019

Language:

english

File:

PDF, 784 KB

english, 2019

48

Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers that Bind HIV-1 Integrase with Picomolar Affinity

Rose, Kevin M., Alves Ferreira-Bravo, Irani, Li, Min, Craigie, Robert, Ditzler, Mark A, Holliger, Philipp, DeStefano, Jeffrey J.

Journal:

ACS Chemical Biology

Year:

2019

File:

PDF, 784 KB

2019

49

Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer

Tuske, Steve, Zheng, Jie, Olson, Erik D., Ruiz, Francesc X., Pascal, Bruce D., Hoang, Anthony, Bauman, Joseph D., Das, Kalyan, DeStefano, Jeffrey J., Musier-Forsyth, Karin, Griffin, Patrick R., Arnold

Journal:

Current Research in Structural Biology

Year:

2020

File:

PDF, 4.07 MB

2020